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were the first to find that GLC induced melanin production in B16 melanoma cells in a dose-dependent manner by upregulating the tyrosinase and Trp-2 genes ( 2 O 2 -induced melanocyte apoptosis, and GR protected melanocytes from oxidative stress by reducing ROS production in cells via activation of the Nrf2/HO-1 pathway (Mou et al., 2019)

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3 mg daily for 30 days, then titrate to 7 mg for at least 30 days, then up to the max dose if necessary which is 14 mg per day