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The release and function of coagulation and fibrinolytic factors (e.g., thrombomodulin, protein C and protein S, thrombin and antithrombin activation, tissue factor pathway inhibitor, platelet activation and adhesion) are under endothelial control, which is highly dependent on NO production

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Clinical evidence demonstrates significant therapeutic benefits of GLP-1RAs in the management of psoriasis

Conclusions/interpretation A dose-dependent superiority on glycaemic efficacy and body weight reduction was evident with tirzepatide vs placebo, GLP-1 RAs and basal insulin