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The complete switching guide covers the clinical reasoning behind each approach in more detail

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Firstly all three strains, the GDH2 and GDH3 deletion mutants and the wild-type strain, grown in MM medium were compared to investigate the metabolic differences between mutant and wild-type strains during the morphological transition ( gdh2 -MM vs WT-MM, gdh3 -MM vs WT-MM)

Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state