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Many people take it alongside other medications that also cause fatigue

Initial concerns were raised after findings from the cardiovascular outcome trial (CVOT), Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes 6 (SUSTAIN 6), revealed a greater risk of DR-related complications, defined as the need for laser therapy, intravitreal injections, development of vitreous hemorrhage, and blindness, in semaglutide users compared to placebo (3.0% vs 1.8%, HR=1.76, P =.02)

In comparison, research on Wegovy suggests it supports an average weight loss of around 16% after one year, 9% less than Zepbound

When fat is removed through weight loss, it becomes overstretched and unable to snap back to its original form