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Moreover, some combinations may help mitigate the side effects associated with individual drugs or even provide supplementary health benefits, such as weight loss or reduced blood pressure, which are particularly beneficial in the diabetic population

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Finally, restrain-free production run was carried out for each simulation, with a time step of 2 fs in the NPT ensemble at 310 K and 1 bar using the Nose-Hoover thermostat and the semi-isotropic Parrinello-Rahman barostat 61 , respectively

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