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Over time, tolerance develops, which often leads to increased use beyond prescribed doses, dependence, and compulsive drug-seeking behavior

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Radiology 291 , 196202, (2019)

The overall pattern and frequency of adverse events during the longer-term premarketing trials was similar to those described in Table 1, though several of the most common events were reported by a greater proportion of patients with long-term use (e.g., nausea was reported in 40% of patients treated with CHANTIX 1 mg twice daily in a one year study, compared to 8% of placebo-treated patients)