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The benefit of SGLT2i therapy beyond improved glycaemic control was first reported in the EMPA-REG study which reported a reduced incidence of major adverse cardiovascular events in patients with type 2 diabetes [19]

DNA extraction and telomere length measured by qPCR DNA from human cell lines (21NT, BT474, IBR.3, and HMEC) was isolated using the Wizard genomic DNA purification kit and protocol from Promega (A1120)

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The physical examination should include special reference to blood pressure, breasts, abdomen, and pelvic organs, including cervical cytology, and relevant laboratory tests