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However, NADP + and NADPH levels in frozen blood differ from fresh blood due to NADPH oxidation during the freeze-thaw cycle

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In this regard, the mitochondria-targeted SOD mimetic Mito-tempo has been shown to protect against APAP hepatotoxicity, while Tempo, which exhibits SOD activity but without its specific mitochondrial targeting, failed to protect against APAP-induced liver injury ( - generation in APAP hepatotoxicity

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