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Wolswijk, G

5 For example, recent preclinical and clinical observations highlight the role of gut-derived peptides such as GIP, GLP-2, and to a lesser extent, GLP-1 in the maintenance of overall skeletal health ( Figure 2 ), 6,7,8 opening new avenues for the understanding and potential treatment of bone disorders

Among these discussions, recurring themes emerge around gut-related discomforts such as bloating, fluctuating energy, and inconsistent appetite control

IGF-1 directly stimulates osteoblast proliferation and collagen synthesis, and it plays a critical role in the coupling of bone formation and resorption during remodeling