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Other criteria add that symptoms must respond to treatment that prevents either MC degranulation or MC mediators like histamine receptor blockade, mast cell stabilizers, leukotriene antagonists, and 5-lipoxygenase inhibitors (4, 5)

These drugs render type 2 diabetes more manageable by lowering insulin resistance and A1C levels through the inhibition of the release of glucagon, a hormone that elevates blood sugar levels

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These factors are crucial in the premature clearance of erythrocytes from circulation, a mechanism similar to that in HbE/-thalassemia [414]