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4.1 The ApelinAPJ axis Apelin was identified as the endogenous ligand for the APJ receptor, a G proteincoupled receptor structurally related to the angiotensin II type 1 receptor but functionally distinct from the reninangiotensin system ( Despite these favorable metabolic effects, enthusiasm for apelin-based therapeutics waned due to its potent cardiovascular actions, including vasodilation and positive inotropy

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However, the indirect effects, such as weight loss and improved metabolic health, are highlighted as critical factors in reducing the risk of liver-related complications

The cardiovascular benefit extends beyond lipid numbers, as these medications also reduce inflammation markers linked to heart disease risk