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PMID 40465419 characterised hexarelin as the primary hepatic metabolite of alexamorelin a structurally related compound from which hexarelin is generated by carboxypeptidase-mediated C-terminal alanine cleavage (alexamorelin signal decreased approximately 150-fold within 3 hours of hepatocyte incubation)

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There was no difference in these benefits between patients who lost 10% or more of their body weight, less than 10%, and those who gained weight while taking GLP-1s

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