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For those with contraindications to, or personal preferences against, using pharmacologic therapies, the following natural supplements have evidence to support their use in managing perimenopausal symptoms: Phytoestrogens , found in soy, beans, flax seeds, and cruciferous vegetables, are plant compounds that may support the reduction of menopausal symptoms (5)

These enzymes are rate-limiting in the production of ceramides, which constitute approximately fifty percent of the intercellular lipid matrix and are absolutely essential for maintaining barrier impermeability

Denitrosylate and live longer: how ADH5/GSNOR links mitophagy to aging