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71,533,601,602,603,604 Morphological atrophy of astrocytes develops in a brain-region-linked fashion, starting first in the entorhinal and prefrontal cortices (which are, incidentally, the most vulnerable to AD) and then spreading to hippocampus

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The increased production of pro-inflammatory cytokines, such as interleukin 1 or interleukin 8, greatly impacts the biological function of the cells, resulting in skin lesions and deterioration of skin appearance, as well as the accumulation of eumelanin, leading to the formation of skin spots