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Drug Targets 15 , 423431 (2014)

In orthopedics, a key challenge is ensuring that tumor-suppressive nanorobots do not impair normal osteogenesis, necessitating a precise balance between cytotoxicity against cancer cells and biocompatibility with bone marrow stem cells ( 4 Nanorobot clinical translation: biosafety, ethics, and regulatory challenges 4.1 Biohybrids and biosafety Biohybrid nanorobots significantly enhance in vivo task execution efficiency and biocompatibility by incorporating the physical surface structures and biological functional properties of natural cells or vesicles

Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome