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One idea is to enhance the activity of amino acid metabolism of CAR-T cells by adding cytokines that promote the expression of transporters related to amino acid metabolism, such as SLC1A5, SLC3A2 and SLC7A5, or directly importing transcripts encoding these AATs into T cells

Acta Pharm Sin B 9(6):11131144 [DOI] [PMC free article] [PubMed] [Google Scholar] Li CSW, Sweeney K, Cronenberger C (2020) Population pharmacokinetic modeling of PF-06439535 (a bevacizumab biosimilar) and reference bevacizumab (Avastin((R))) in patients with advanced non-squamous non-small cell lung cancer