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30,31 It is important to note that all studies were very small (maximum 18 participants), and looked at acute or short-term (up to 9 days) supplementation
Participants receiving 1 mg per day of AOD 9604 lost approximately 2.6 kg compared to 0.8 kg in the placebo group
Historically, such behavioral complexity was viewed as a disqualifying feature for drug development, as CNS-acting agents were associated with unpredictable neuropsychiatric liability and high regulatory barriers ( 5.4 Translational lessons from abandoned appetite peptides The historical trajectory of appetite and behavioral peptides reveals a recurring pattern: early development efforts often failed due to inadequate control over exposure, insufficient combination strategies, or overly conservative interpretations of side effects
Illustratively, female Lewis rats with jugular vein catheters (Harlan, regular rodent diet) are given a single subcutaneous injection of test compound, such as EC 1669 at 500 nmol/kg
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