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3), with improvements in multiple cardiometabolic risk factors (Table 2) [21]
GLP-1R agonism reverses the neuronal toxicity associated with the synucleinopathy, through reduction of oxidative stress, improved mitochondrial and lysosomal function, reduced aggregation of -synuclein, and enhanced neuronal viability
Semaglutide acts on receptors in the brain to reduce hunger, increase feelings of fullness, and slow gastric emptying
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