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In one of the initial long-term pivotal studies of patients with type 1 and insulin-requiring T2D where full-dose pramlintide was added to existing insulin regimens in double-blind fashion without titration, it was observed that the severe hypoglycemia event rate during the first 4 weeks of therapy was higher in the pramlintide group compared with the placebo group

Patients with type 2 diabetes or obesity may have additional risk factors for infections or other conditions that cause lymphadenopathy, making it essential to evaluate swollen lymph nodes thoroughly rather than automatically attributing them to GLP-1 therapy

That's an 8 variance in active lipotropic load

10.1016/j.intimp.2021.108175 52 XuZ.ZhangQ.DingC.WenF.SunF.LiuY.et al (2023)