The presence of oxidized low-density lipoprotein (ox-LDL) drives atherogenesis by inducing oxidative stress, mitochondrial dysfunction, expression of proinflammatory cytokines and chemokines including interleukin (IL)-1, IL-6, and monocyte chemoattractant protein 1 (MCP-1), adhesion molecules including vascular cellular adhesion molecule 1 (VCAM-1) and E-selectin, and downregulating expression of the Krppel-like factor 2 (KLF2) transcription factor
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This means: They underwent extensive clinical trials Dosing, purity, and manufacturing are strictly regulates Safety and efficacy were evaluated in thousands of patients The formulation is standardized and consistent FDA approval ensures that what you are receiving has been rigorously tested for both safety and predictable results