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As fat cells grow larger, they begin to overproduce an enzyme called NNMT (nicotinamide N-methyltransferase)

It is noteworthy that the lipid peroxidation and metabolic disorders of intracellular LOOHs are mainly related to iron metabolism (Figure 1B), glutathione (GSH)-dependent pathway (Figure 1C), and coenzyme Q 10 (CoQ 10 )-dependent pathway (Figure 1D)

doi:10.1002/dta.2152

Experimental investigations have examined the relationship between NNMT inhibition and regulatory pathways involving nicotinamide turnover, methylation dynamics, transcriptional control mechanisms, and downstream signal transduction processes