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Other effects require reporting to a medical team as soon as possible, including: An allergic reaction, including rashes, itching, hives, and a swollen face, tongue, throat, or lips High blood sugar symptoms Other liver damage symptoms, including pain in the upper-right abdomen, appetite loss, dark yellow urine, a yellow tint in the skin or eyes known as jaundice, and feeling unusually weak or tired Tingly, numb, or painful feet Following a balanced diet means that most people are unlikely to develop a B vitamin deficiency

The ATTAIN-MAINTAIN Phase 3 trial specifically evaluated this scenario, testing whether patients who had achieved weight loss with injectable GLP-1 receptor agonists (semaglutide or tirzepatide) could switch to oral orforglipron while maintaining their weight loss

(2018) 10(4):a022293

Acromegaly: pathogenesis, diagnosis, and management