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The available data remain largely preclinical or based on limited observations, and its non-selectivity is also its main limitation: by affecting multiple receptors, it is associated with varied effects reported in the literature
The financialized nature of the pharmaceutical industry exacerbates these challenges
Other groups have also modified the primary sequence of glucagon to confer increased GLP-1R potency
Ziegler AG, Achenbach P, Berner R et al (2019) Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol
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