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393,394 For instance, miR-146a regulates inflammatory responses by targeting IRAK1 and TRAF6, and its decreased expression contributes to increased inflammation in DPN

The analysis presented here suggests that although both compounds are safe and offer substantial health benefits and are involved in both autophagy and mitophagy, the role of UroA in mitophagy places it as a targeted intervention for mitochondrial health, whereas the broader influence of spermidine on autophagy and metabolic regulation may provide more comprehensive anti-ageing effects

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