Method Absorption Rate Advantages Disadvantages Oral pills 1.2-40% depending on intrinsic factor Convenient, widely available Poor absorption, especially with age or GI issues Sublingual Slightly better than pills No need for intrinsic factor, easy to use Still less effective than injectable forms In-clinic IM injection Nearly 100% Highly effective, professionally administered Requires clinic visits, potential travel and waiting time At home B12 injection Nearly 100% Highly effective, convenient, no travel needed Requires training, prescription, and comfort with self-injection IV infusion 100% Immediate delivery to bloodstream Most expensive, requires professional administration For many people especially those with serious deficiencies, digestive disorders, or pernicious anemia at home B12 injection offers the sweet spot of effectiveness and convenience
Watch the site for excess redness, swelling, or signs of infection
Documentation for the code 96372 CPT must show the order, the drug administered, dose/route/site, administration time, and the provider or staff who performed the injection
Sublingual Tablets or Drops: You place these under your tongue, allowing the B12 to be absorbed directly into the rich network of blood vessels there, completely bypassing the digestive system
