Consequently, viral reactivation may occur in neurons, where infectious virus is produced and expanded within the ganglia, with viral particles then traveling back to the original site of infection ( Interestingly, some studies have reported that the cell coactivator termed host cell factor-1 (HCF-1), which is found in the cytoplasm of sensory neurons, is transported to the nucleus of these cells in response to HSV-1 reactivation stimuli, providing some potential clues regarding the molecular reactivation of HSV-1 from neurons ( in vivo study with mice showed that there is a positive correlation between the number of latently-infected neurons in the TG and the likelihood of viral reactivation
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J Med Chem 58:73707380 Lee TS, Park EJ, Choi M, Oh HS, An Y, Kim T, Kim TH, Shin BS, Shin S (2023) Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats
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