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pooled the data from four cohort studies and three-case control studies that reported data on the association between prenatal tobacco exposure and schizophrenia [ Preclinical research Preclinical studies have also sought to determine whether there is an association between PNE and ones risk for developing schizophrenia while controlling for the potential confounds of clinical studies [ An initial study in Wistar rats examined the affect that prenatal cigarette smoke exposure (PCSE) has on locomotor activity and cholinesterase activity in rats following either PCSE and/or ketamine treatment (acute subanesthetic doses of 5, 15, and 25 mg/kg) in adulthood and their potential relevance to schizophrenia [ A follow-up study investigated the association between cigarette smoke during the prenatal period as a causative factor for obstetric abnormalities that lead to cognitive and behavioral changes associated with schizophrenia [ Autism spectrum disorder (ASD) Autism spectrum disorder (ASD) is a neurodevelopmental disorder thats characterized by the presence of restricted interests and repetitive behaviors and deficits in social communication [ de novo and inheritable gene variations [ In utero exposure to nicotine has deleterious effects on prenatal neurodevelopment [ Clinical research Clinical studies addressing the association between maternal smoking during pregnancy and ASD risk in offspring have yielded varying outcomes

For relapse prevention interventions, the evidence does not support the use of any specific behavioural interventions and there is little evidence for the use of extended bupropion or NRT in preventing relapse