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doi:10.1016/S0140-6736(06)69705-5

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These include several deiodinase enzymes that are essential for the generation of thyroid hormones, several glutathione peroxidases that are important for the conversion and detoxification of compounds with reactive oxygen atoms, and several proteins of unknown function

If it occurs, HIV-associated oral mucosal melanin hyperpigmentation usually develops within 2 years of contracting HIV or within a few months of starting antiretroviral treatment with the drug zidovudine