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472 The right hippocampus, parahippocampal gyrus, left amygdala, and the whole caudate nucleus all had functional changes in activity in MDD patients compared to healthy controls, indicating that the temporal lobe might be involved in the pathogenesis of MDD

However, the main limitation of our approach is that, by the direct and acute injection of the A-anticalin in a defined small brain area, we were only able to investigate local short-term effects of the application

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