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Yet, GM has been reported to be capable of manipulating vitamin D activity either through upregulating VDR intestinal expression by producing short-chain fatty acid such as butyrate [107], or through competing it for VDR by lithocholic acid, a secondary bile acid [108]

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This is one reason the safety and side effect profile of GH secretagogues tends to be more favourable than that of exogenous HGH, particularly regarding IGF-1 overshoot and glucose dysregulation

The pVSD and pore-forming helices adopt a domain-swapped topology, whereby the pVSD of one subunit contacts the pore-forming region of a neighboring subunit