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The objective was to evaluate the effectiveness and safety, with a specific focus on cardiovascular safety, of tirzepatide, a novel dual GIP and GLP-1 receptor agonist, compared to insulin glargine in adults with type 2 diabetes and a high risk of cardiovascular events who have not achieved adequate control with oral glucose-lowering medications.This phase 3 study was conducted at 187 sites across 14 countries on five continents

Understanding How Tirzepatide and Semaglutide Work Weight loss medications like tirzepatide and semaglutide work by targeting hormones involved in appetite regulation and metabolic control

Schuckit MA

We further examined whether acute administration of tirzepatide (GLP-1/GIP) and retatrutide (GLP-1/GIP/glucagon), which is currently undergoing testing in clinical trials, would recapitulate or enhance the effects observed with semaglutide