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Their co-expression amplifies T-cell dysfunction within the TME beyond the effects of either immune checkpoint alone ( 3.5 PD-1, PDL-1, and PDL-2 The programmed cell death protein 1 (PD-1) receptor and its ligands, programmed death-ligand 1 (PD-L1) and PD-L2, are essential components of the immune checkpoint pathway that regulates immune homeostasis

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Cigarette smoking causes 87 percent of lung cancer deaths

BRAND STRATEGY AND INTEGRATED MARKETING COMMUNICATION (IMC). Journal of Advertising 34.4 (2005): 81-92