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Preserving Muscle as You Age Aging is accompanied by a natural decline in muscle mass and strength, a condition known as sarcopenia

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This is highly relevant as PKA-RI aggregates undergo LLPS to form biomolecular condensates 65 which spatially restrict PKA activity, leading to signal compartmentalisation 25 , explaining why the direct presence of endosomal GLP-1R at ERMCSs is required to assemble this signalling hub, and uncovering a new modality of GLP-1R signal transduction which involves the local assembly of a biomolecular condensate containing not only signalling mediators such as SPHKAP/PKA, and also presumably adenylate cyclase, but also downstream targets for PKA phosphorylation such as the MICOS complex and other ERMCS components, some likely found amongst the active GLP-1R interactors identified in our interactome analysis

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