negatives of semaglutide Semaglutide: Double-edged Sword with Risks and Benefits Pros and Cons of Semaglutide

Without adequate collagen turnover, the result is sagging, loose skin that may eventually require surgical intervention

[DOI: 10.1056/NEJMoa1105816] Wing R.R., Phelan S

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DOI: 10.1016/0092-8674(93)90415-M IGF-1 Axis and Anabolic Signalling Landmark studies establishing the GH/IGF-1 axis including the somatomedin hypothesis refinements by LeRoith, Laron, and colleagues defined IGF-1 as the primary mediator of GHs anabolic and growth-promoting effects, confirmed the liver as the primary source of circulating IGF-1, and established the research framework for GH deficiency and GH replacement biology that underpins current pre-clinical GH axis research