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[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Bech EM, Voldum-Clausen K, Pedersen SL, et al

Increased Risk of Colonic Complications: Although the research is still emerging, some healthcare providers believe the digestive changes caused by semaglutide may increase the risk of certain complications, especially in those already susceptible to gastrointestinal conditions like Crohns disease or irritable bowel syndrome

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Option B (valproate) effective but contraindicated in suspected mitochondrial disorders, liver disease, and pregnancy (teratogenic)