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In all, persistent tissue injury provokes chronic inflammation and an increase of pro-fibrotic factors, such as TGF-1, ROS, PAI-1, ROCK, TNF, and TIMPs, which induce the phenotype transformation of precursor cells to myofibroblasts

Articles pertinent to the aim of the review were selected based on the relevance of the title and abstract in the topic by four authors (R.M.R., E.M., L.C., and C.V.) and then were critically evaluated by all authors

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