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if more than 5 days remain, administer as soon as possible NICE guidance (TA875) on semaglutide for managing overweight and obesity emphasises shared decision-making in weight management

Systemic hormone effects: GLP-1 receptors exist throughout the body, including in the heart, blood vessels, kidneys, and liver

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However, retatrutide, as a multi-receptor agonist, may have broader effects on metabolism and potentially unique side effects as clinical trials continue to uncover its full profile