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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

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It is thought that high levels of stress deplete the body of stored Vitamin B12

The partial pressure of oxygen in arterial blood (Pa o2 ) and ascorbate were restored to normal levels, and BAL fluid protein concentration decreased by about 35%