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Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway

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7.1.1.2 Small-molecule inhibitors Small-molecule inhibitors that block cytokine signaling pathways, such as the Janus kinase (JAK) inhibitors, have shown promise in reducing inflammation in I/R models (Panda et al., 2024)