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however, there were important limitations to consider, including small sample sizes, a lack of long-term observation, the use of a single species or strain, the lack of in-depth exploration of cellular or molecular mechanisms, failure to assess other aspects of reproductive function, a lack of validation of the clinical relevance, and a failure to consider individual differences in drug dosages

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Lancet 2001;358:17549.ArticlePubMed 33

While the bellwether trials will not be binding for other cases, their outcomes are expected to influence potential Paragard IUD settlements, which could prevent the need for individual trials across the country