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Second, to slow down the excretion out of the body and increase half-life in the blood, peptides can be fused with the Fc fragment of an antibody and protein scaffolds such as Staphylococcus A antigen (Affibody) or conjugated with polyethylene glycol and fatty acids to enables the peptides to bind to albumin

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Common side effects for both include: Mild injection-site reactions (small bump or redness, resolves within hours) Transient water retention in the first 1-2 weeks Vivid dreams in the first week (often a positive sign of deepening REM cycles) Occasional brief flushing sensation immediately after injection more common with CJC-1295/Ipamorelin Mild tingling or fatigue in the first few doses, typically resolves quickly Less common but serious considerations include effects on glucose tolerance (worth monitoring if you're insulin-resistant or diabetic), the potential for joint discomfort if dose is too high, and any contraindications related to active cancer, severe pituitary issues, or specific medications

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