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Some of the examples are as follows: [3] Autoimmune destruction of astrocyte endfeet that contact and envelop blood vessels is associated with CNS inflammation and a form of multiple sclerosis Rasmussen's syndrome autoantibody destruction of astrocytes causes seizures In Alexander's disease, a dominant, gain-of-function mutation of the gene encoding GFAP is associated with macro-encephalopathy, seizures, psychomotor disturbances, and premature death