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These mtROS suppress autophagic clearance by oxidatively inactivating the IRS-1/PI3K pathway [413], while simultaneously activating HIF-1 to promote glycolysis, creating a nutrient-rich microenvironment for MTB

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found that signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs)