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13, 54 Our mechanistic investigations demonstrated that BSO+L-PAM induced significant increases in mitochondrial depolarization, cleavage of caspase-3, caspase-9, poly ADP ribose polymerase and DNA fragmentation

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Patients should never stop a GLP-1 medication without consulting their prescribing physician, particularly if it is part of a diabetes management plan

However, in CVOTS there was not any cardiovascular benefit and saxagliptin increase heart failure hospitalization, vildagliptin is not marketed in the USA, so there is no data associated with CVOT (Table 2)