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leaky gut) plays a key role in IBS is still unknown and the subject of ongoing research Avoiding regular exposure to excessive amounts of alcohol and NSAIDs (unless under instruction of a medical professional) may be useful for reducing gut irritation if you have IBS There are currently no treatments for leaky gut (such as supplements or special diets) that are supported by strong scientific evidence A low FODMAP diet might have effects on normalising intestinal barrier function in animal models under conditions of psychological stress, however this is yet to be shown in humans