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34 In heterozygous (monoallelic) ABCB4 transporter mutations, the phenotype is typically less severe, as in LPAC, ICP, ductopenic cholestatic liver disease, and drug-induced liver injury

Since evidencebased appropriate dosage for NAC in MS patients is scarce, the recommended dose was chosen based on the results of a previous study on patients with high oxidative stress conditions, which indicated that a higher dose than 1200 mg NAC per day might not be needed for GSH increments accompanied by gastrointestinal side effects

doi: 10.1007/s00395-021-00873-9 Darsalia V, Hua S, Larsson M, et al

diff groups received antibiotics to induce gut dysbiosis, followed by C