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Intrarectal instillation of AA is followed by protonation and migration of molecule of AA into colonic microflora, resulting in destruction of colonic epithelium, increased bacterial influx into the lamina propria, and enhancement of the activated enterocytes to generate a variety of cytokines (Soliman et al

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Research has shown that MC4R activation in specific hypothalamic nuclei, particularly the paraventricular nucleus (PVN), leads to the release of oxytocin and other neuropeptides that facilitate both the psychological experience of desire and the physiological responses of arousal

J Clin Invest 83:326330 Hirschberg R, Kopple JD (1992) The growth hormone-insulin-like growth factor I axis and renal glomerular function