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The experiment was carried out in a barrier environment, with a room temperature of 2325C, relative humidity of 5070%, light/dark cycle for 12 h, and free diet and water

patients and healthcare professionals are encouraged to report any suspected adverse reactions at yellowcard.mhra.gov.uk

Seek medical attention if fatigue is accompanied by: Signs of dehydration Decreased urine output, dark urine, dizziness upon standing, dry mouth, or rapid heartbeat Symptoms suggesting hypoglycemia Shakiness, sweating, confusion, irritability, or palpitations (particularly in patients taking insulin or sulfonylureas, which may need dose adjustment) Indicators of thyroid dysfunction Cold intolerance, unexplained weight changes beyond expected loss, hair thinning, or constipation Severe abdominal pain Especially if radiating to the back, which could indicate pancreatitis (a rare but serious side effect) Gallbladder symptoms Right upper quadrant pain, fever, or yellowing of the skin/eyes (jaundice) Mental health changes New or worsening depression, anxiety, suicidal thoughts, or loss of interest in usual activities Call 911 or seek emergency care immediately for: Cardiovascular symptoms Chest pain, severe shortness of breath, or irregular heartbeat Neurological symptoms Sudden weakness, facial drooping, difficulty speaking, or severe headache Severe allergic reaction Rash, itching, swelling (especially of face/throat), severe dizziness, or trouble breathing Patients with pre-existing medical conditions such as hypothyroidism, anemia, or chronic kidney disease should maintain regular monitoring as recommended by their healthcare provider

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