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309624) at 1.60- resolution revealed that the Kelch repeats fold into a drum-shaped, 6-bladed -propeller structure with an inner cavity buried in the central core opening on the top and bottom of the globular spheres (42, 43)

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Building on this foundation, the gradual exploration of intelligent integration with biosensing technologies and controlled drug delivery systems should be pursued to lay the groundwork for personalized, adaptive, closed-loop therapy (57, 67)