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Glycolysis and the TCA cycle serve as core hubs for energy production, while the PPP primarily supplies the cell with NADPH (to maintain redox balance) and ribose-5-phosphate (for biosynthesis) ( 2 substrates utilized in oxidative phosphorylation (OXPHOS) ( Abnormal glucose metabolism in COPD patients is not driven by a single factor but rather reflects systemic dysregulation across the three core energy metabolic pathways: glycolysis, the PPP, and the TCA cycle

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Following this, the lung sections were scanned using a Mirax slide scanner, and the lung/tumor areas were automatically scored using an algorithm programmed and executed with the Definiens software suite